The House Dust Mite (HDM) is a cosmopolitan pyroglyphid that lives in human habitation. Dust mites feed on organic detritus, such as flakes of shed human skin, and flourish in the stable environment of dwellings. House dust mites are a common cause of asthma and allergic symptoms worldwide. The mite’s gut contains potent digestive enzymes (notably proteases) that persist in their feces and are major inducers of allergic reactions such as wheezing. The mite’s exoskeleton can also contribute to allergic reactions. The European house dust mite (Dermatophagoides pteronyssinus) and the American house dust mite (Dermatophagoides farinae) are two different species, but are not necessarily confined to Europe or North America; a third species Euroglyphus maynei also occurs widely. Unlike scabies mites or skin follicle mites, house dust mites do not burrow under the skin and are not parasitic.